• Physical Injury – triggers inflammation
• Everyday wear and tear - Repetitive and excessive force on a joint may wear down the supporting tissues of the joints
• Weight Bearing joints - Knee, hock, fetlock, pastern and coffin joints are more prone to be arthritic since they endure the majority of the concussive forces
• Poor conformation may cause abnormal forces, placing additional strain on joints
• Other injury – bacterial infection (septic arthritis) and joint fractures will stimulate an inflammatory response